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Madrigal Expands its MASH Pipeline with Exclusive Global Licensing Agreement for Six Preclinical siRNA Programs February 11, 2026 PDF Version Company advances its leadership in MASH with an expande
One-line summary: Madrigal has expanded its MASH treatment pipeline by licensing six preclinical siRNA programs targeting genetic drivers of disease to complement its foundational therapy Rezdiffra.
Citations: 4 · Risk: 1 High / 0 Medium / 0 Low
A new, potential treatment for nonalcoholic steatohepatitis with fibrosis Skip to content Menu Medical Home Life Sciences Home Become a Member Search Medical Home Life Sciences Home About Functional F
One-line summary: A novel therapeutic approach inducing cytoglobin (CYGB) in hepatic stellate cells shows promise for treating nonalcoholic steatohepatitis (NASH) with fibrosis by mitigating oxidative DNA damage.
Citations: 4 · Risk: 1 High / 0 Medium / 0 Low
Auto-aggressive immune cells cause liver immune pathology in non-alcoholic steatohepatitis Skip to content Menu Medical Home Life Sciences Home Become a Member Search Medical Home Life Sciences Home A
One-line summary: Auto-aggressive CD8 T cells, activated by metabolic stimuli rather than pathogens, drive liver tissue destruction and pathology in non-alcoholic steatohepatitis (NASH).
Citations: 3 · Risk: 1 High / 0 Medium / 0 Low
Potential leptin therapy for nonalcoholic steatohepatitis Skip to content Menu Medical Home Life Sciences Home Become a Member Search Medical Home Life Sciences Home About Functional Food News Health
One-line summary: Leptin therapy using metreleptin shows promise in reducing liver fat and improving nonalcoholic steatohepatitis (NASH) in patients with low leptin levels, including those with partial lipodystrophy.
Citations: 4 · Risk: 1 High / 0 Medium / 0 Low
Researchers uncover new genetic link to non-alcoholic steatohepatitis Skip to content Menu Medical Home Life Sciences Home Become a Member Search Medical Home Life Sciences Home About Functional Food
One-line summary: A point mutation in the tyrosinase gene increases susceptibility to diet-induced NASH in albino mice via altered cholesterol uptake in the intestine, suggesting genetic influence on NASH pathophysiology.
Citations: 2 · Risk: 1 High / 0 Medium / 0 Low
Discovery could pave the way for developing therapies to treat nonalcoholic steatohepatitis Skip to content Menu Medical Home Life Sciences Home Become a Member Search Medical Home Life Sciences Home
One-line summary: Obesity-induced cleavage and inactivation of macrophage receptor TREM2 impairs clearance of damaged hepatocytes, promoting chronic liver inflammation and nonalcoholic steatohepatitis (NASH) development.
Citations: 4 · Risk: 1 High / 0 Medium / 0 Low
Researchers find possible genetic basis and mouse model for nonalcoholic steatohepatitis Skip to content Menu Medical Home Life Sciences Home Become a Member Search Medical Home Life Sciences Home Abo
One-line summary: Researchers identified the SRSF1 gene as a protective factor against DNA damage in liver cells, and its absence in a novel mouse model replicates all hallmarks of nonalcoholic steatohepatitis (NASH), proposing a new genetic basis for the disease.
Citations: 3 · Risk: 1 High / 0 Medium / 0 Low
Non-alcoholic steatohepatitis progression blocked by ginger essential oil Skip to content Menu Medical Home Life Sciences Home Become a Member Search Medical Home Life Sciences Home About Functional F
One-line summary: Ginger essential oil (GEO) demonstrated potential in preventing progression of non-alcoholic steatohepatitis (NASH) in a murine model by modulating inflammation, oxidative stress, and gut microbiota.
Citations: 2 · Risk: 1 High / 0 Medium / 0 Low
Researchers identify a previously unknown cellular barrier in the brain VIB and Ghent University researchers have identified and characterized a previously unknown cellular barrier in the brain, which
One-line summary: Researchers discovered and characterized a novel dynamic cellular barrier at the base of the choroid plexus that segregates brain, CSF, and blood compartments and is vulnerable to systemic inflammation.
Citations: 1 · Risk: 0 High / 0 Medium / 1 Low
Nasal COVID vaccine boost increases IgA responses linked to variant neutralisation Skip to content Menu Medical Home Life Sciences Home Become a Member Search Medical Home Life Sciences Home About Fun
One-line summary: An intranasal COVID-19 vaccine booster significantly enhances mucosal secretory IgA responses, improving neutralization of variants and complementing systemic immunity.
Citations: 4 · Risk: 1 High / 1 Medium / 0 Low